Overview             package:MetaNetwork             R Documentation

_M_e_t_a_N_e_t_w_o_r_k _p_a_c_k_a_g_e

_D_e_s_c_r_i_p_t_i_o_n:

     MetaNetwork maps metabolite quantitative trait loci (mQTLs)
     underlying  variation in metabolite abundance in individuals of a
     segregating population  with a two-part model to account for the
     often observed spike in the  distribution of metabolite data.
     MetaNetwork predicts and visualizes  potential associations
     between metabolites using correlations of mQTL  profiles, rather
     than of abundance profiles. Simulation and permutation  procedures
     are used to assess statistical significance.

_N_o_t_e:

     To install MetaNetwork package:
      Download the MetaNetwork package from: <URL:
     http://gbic.biol.rug.nl/supplementary/2007/MetaNetwork>
      (Windows/RGui) click 'Packages'; 'install package(s) from local
     zip files'; browse to the MetaNetwork zip file.

     MetaNetwork requires the 'qvalue' package for false discovery rate
     control:
      (Windows/RGui) click 'Packages'; 'Install package(s)...'; select
     CRAN mirror; select qvalue.

     The developers of MetaNetwork thank Gonzalo Vera, Bruno Tesson and
     Richard Scheltema for helping to develop this R-package, and
     Martijn Dijkstra and  Rainer Breitling for helping to predict
     multiple peaks belonging to the same  metabolite

_A_u_t_h_o_r(_s):

     Jingyuan Fu <j.fu@rug.nl>,  Morris Swertz <m.a.swertz@rug.nl>,
     Joost Keurentjes <Joost.Keurentjes@wur.nl>,  Ritsert Jansen
     <r.c.jansen@rug.nl>

_R_e_f_e_r_e_n_c_e_s:

     Please cite publication below when reporting results produced
     using this package:
       Fu J, Swertz MA, Keurentjes JJB, Jansen RC. MetaNetwork: a
     computational tool for the  genetic study of metabolism. Nature
     Protocols (2007).

