POPS
type: SIO_000616
description: Prospective cohort

BIG (Brain Imaging Genetics)
type: SIO_000616
description: MRI available

HEBON
type: SIO_000616
description: Prospective cohort, family-based

EPOZ
type: SIO_000616

AGORA
type: SIO_000616
description: Most samples are from child-parent trios - 6,860 families (3,747 birth defects, 905 childhood cancers, and 2,208 population-based controls).

Hippocrates
type: SIO_000616
description: NT and HT individuals, 24-hour BP, hormonal status, IMT, PWV, etc

Nijmegen Biomedische Studie
type: SIO_000616
description: http://www.nijmegenbiomedischestudie.nl

Doetinchem Cohort Study
type: SIO_000616
description: Population based cohort, baseline 1987-1991, follow-up every five years. Fifth round ongoing (2008-2012). Lifestyle, risk factors and diseases: cardiovascular, diabetes, COPD, cancer, musculoskeletal

LRGP
type: SIO_000616
description: Prospective cohort

EPIC-NL
type: SIO_000616
description: Prospective cohort, follow up cancer, CVD, type 2 diabetes, mortality

LifeLines
type: SIO_000616
description: Final target n=165.000. Trio design (http://www.lifelines.nl/lifelines-research/study-design-and-organisation/study-design); Chronic diseases. Overview of collected data: http://www.lifelines.nl/upload/file/Research/overview+measurements+lifelines+2012.pdf.

Vla-Vla
type: SIO_000616
description: studie naar rol omgevingsfactoren op ontstaan COPD

Doetichem cohort
type: SIO_000616

Family and Health
type: SIO_000616
description: 400 nuclear families with 2 children. Study is focussed on family processes, for instance (substance-use-specific) parenting, in relation to various health-related behaviours in adolescence, like smoking, alcohol use, and eating behaviour

Prevention of Renal and Vascular End-stage Disease
type: SIO_000616
description: Prospective cohort; focus on renal and cardiovascular disease. 8592 subjects measured at baseline and during 5 follow-up screening rounds.

TRacking Adolescents' Individual Lives Survey - Population sample
type: SIO_000616
description: Prospective cohort. Since 2001, and starting at age 11. Representative for general population See: www.trails.nl.

GECKO
type: SIO_000616
description: focus on obesity; children being followed from birth to adulthood (DNA isolation is ongoing)

N/A
type: SIO_000616
description: wordt gewerkt aan extra 1000

ERGO, Rotterdam study: population-based; outbred
type: SIO_000616
description: Unselected ; population-based ; 45+ ; cancer, cardiovascular, neurological, psychiatric, endocrine, locomotor , ophthalmological , otolarynchological , genetic , hepatic , pulmonary , dermatological , disorders

Generation R
type: SIO_000616
description: Unselected population based study; birth cohort (gwas) and parrents

Erasmus Rucphen Family study (ERF) and patient cohorts: family-based
type: SIO_000616
description: unselected, population-based, family study; GWA: 2800 random en 500 patient series - pcos, preeclampsia, IUGR, glaucoma, Alzheimer, Parkinson, stroke

Ghana
type: SIO_000616
description: Population based

N/A
type: SIO_000616
description: 120 trio's

N/A
type: SIO_000616
description: Familybased, 450 independent cases

PANDA
type: SIO_000616

ABCD
type: SIO_000616
description: Moeders (tijdens zwangerschap): geen DNA, kinderen: filtreerpapiertjes waar DNA uitgehaald kan worden.

NESCOG
type: SIO_000616
description: Data available on cognitive functioning, intelligence, personality traits, various psychiatric behaviors as well as potential environmental moderators

Centrale Biobank (CBB) UMC Utrecht
type: SIO_000616
description: biopten en weefsel als vriesmateriaal en in paraffine

Leiden 85+
type: SIO_000616
description: Prospective cohort

Leiden Longevity Study
type: SIO_000616
description: Biomarkers

Longitudinal Aging Study Amsterdam
type: SIO_000616
description: 3 cohorten, 55+, longitudinaal, Exoom chip in eerste cohort.

EUGENDA
type: SIO_000616
description: Alle 4000 in Nijmegen opgeslagen

PIAMA
type: SIO_000616
description: bloed DNA: leeftijd 4 en 8 en 16 Wanglsijmvlies DNA: leeftijd 8 Neus epihteel DNA: leeftijd 16

KOALA
type: SIO_000616
description: birth cohort, extensive environmental measures; 1600 trio's

Prevasc
type: SIO_000616
description: birth cohort, extensive environmental measures

UMCG COPD
type: SIO_000616
description: 100 asthmatics followed from childhood over 30 years, 280 asthma patients with follow up >30 years from which 200 families with proband with asthma (n=1259), 200 unrelated asthma, asthma trios (n=405), Rhinitis trios (n=226), untreated asthma and controls (n=150), 200 asthmapatients with airway biopsies, followed over >5 years), 75 families with two children with asthma.

N/A
type: SIO_000616
description: Familybased, no. of independent cases 230

KNOOPSGAT
type: SIO_000616
description: birth cohort, extensive environmental measures

WHeezing Illnesses STudy LEidsche Rijn
type: SIO_000616
description: birth cohort, extensive environmental measures, including neonatal lung function and cardiovasc parameters. See http://www.umcutrecht.nl/nl/Subsites/Whistler/Home

Occupational asthma
type: SIO_000616
description: occupational asthma with environmental exposure measures

NELSON
type: SIO_000616
description: RNA van ongeveer 1000 personen

PACMAN cohort
type: SIO_000616
description: Treated children with asthma (4-12yr), lung function measurements, eNO, questionnaire data, pharmacy data. Verwacht aantal eind 2010: 1000

ORIGO
type: SIO_000616
description: Patient based

Polygene
type: SIO_000616
description: Extensively phenotyped

N/A
type: SIO_000616
description: also 800g pellet, serum, cryomaterial

Breast Cancer Outcome Of Mutation carriers
type: SIO_000616
description: Extensively phenotyped, < = 50 years at diagnosis

MINDACT
type: SIO_000616
description: Tumor expression arrays run on all cases

N/A
type: SIO_000616
description: RNA n=800. Nationally coordinated assessment of randomized clinical trials

N/A
type: SIO_000616
description: N=100 Normal + Tumor tissue, extensively phenotyped

N/A
type: SIO_000616
description: Malign + benign tumors

Polygene
type: SIO_000616
description: Extensively phenotyped

SABA
type: SIO_000616
description: Genetic population isolate

GenoMEL, RO-1
type: SIO_000616
description: Familal melanoma

Polygene
type: SIO_000616
description: Extensively phenotyped

N/A
type: SIO_000616
description: extensively phenotyped

LSS
type: SIO_000616
description: Also 300 controls without skin cancer and 100 melanoma patients

EPI-HPV
type: SIO_000616
description: n=1000 (serum, DNA of eyebrow hairs). Organ transplant recipients.

N/A
type: SIO_000616
description: N=100 Normal + Tumor tissue; extensively phenotyped

Polygene
type: SIO_000616
description: Extensively phenotyped

N/A
type: SIO_000616
description: Including 300 bladder cancer, 500 prostate cancer

Polygene
type: SIO_000616
description: Extensively phenotyped

Polygene
type: SIO_000616

Polygene
type: SIO_000616

Polygene
type: SIO_000616

Thyroid cancer
type: SIO_000616
description: Extensive phenotyping; trio setup

GENDER
type: SIO_000616
description: Patient based

Regress
type: SIO_000616
description: Patient based

Prosper
type: SIO_000616
description: Intervention trial

N/A
type: SIO_000616
description: LDL receptor defects; Other categories and index patients available

Lipidpoli
type: SIO_000616
description: Clinic based, 1000 independent; 500 familial

Zutphen
type: SIO_000616
description: Nutrition prospective cohort study

Alpha Omega Trial
type: SIO_000616
description: Nutrition prospective cohort study in post MI patients.

N/A
type: SIO_000616
description: 210 child-parent trios

Peilstationsproject Hart- en Vaatziekten (PPHVZ)
type: SIO_000616
description: Population based

SMART
type: SIO_000616
description: Hospital population-based

Socrates
type: SIO_000616
description: NT and HT individuals, 24-hour BP, hormonal status, IMT, PWV, etc

SMILE
type: SIO_000616
description: Patient based

HAPPY
type: SIO_000616
description: prospective cohort

Utrecht Cardiovascular Pharmacogenetics UCP
type: SIO_000616
description: Case control study, Hypercholesterolemic and hypertensive population. Pharmacy data, questionnaire data, physician data

PAS
type: SIO_000616
description: see PLoS ONE 3(10): e3583. doi:10.1371/journal.pone.0003583

Agnes
type: SIO_000616
description: see PLoS ONE 3(10): e3583. doi:10.1371/journal.pone.0003583

Genetic risk factors in Familial Hypercholesterolemia
type: SIO_000616
description: see PLoS ONE 3(10): e3583. doi:10.1371/journal.pone.0003583

ARREST
type: SIO_000616
description: Population-based, out-of-hospital cardiac arrest

Familial Combined HyperLipidemia
type: SIO_000616
description: Family-based, 23 extended families. 5 yrs follow-up data available for n=201 (21 families)

FCHL-Nijmegen
type: SIO_000616
description: Family-based, 5 yrs follow-up data available for n=502 (13 extended families), 10 yrs follow-up data available for n=162 (12 families)

Vascular disease
type: SIO_000616
description: Control Aortas >380. Coronaries >80. Aortic Aneurysms >200. Vessel wall (paraffin embedded, classified). Frozen material

AtheroRemo-IVUS
type: SIO_000616
description: AtheroRemo-IVUS is a prospective observational study that has enrolled 600 patients with coronary artery disease. At baseline, angiography and intravascular ultrasound-virtual histology (IVUS-VH) have been performed; history, medication, physical examination and electrocardiograms have been recorded; and blood samples have been drawn. The primary study aim is to correlate coronary artery disease imaging phenotype as determined by IVUS-VH with genetic profile. N.B. Co-founder is Prof. Patrick Serruys, who is with the Imperial College, London.

N/A
type: SIO_000616

N/A
type: SIO_000616

N/A
type: SIO_000616

Hoorn Study
type: SIO_000616
description: all extensively phenotyped (1600 more but no DNA); 139 non-diabetic participants with hyperglycemic clamp data.

Utrecht Clamp Cohort
type: SIO_000616
description: 78 non-diabetic participants with hyperglycemic clamp data.

HEFAS
type: SIO_000616
description: 250 families

N/A
type: SIO_000616

N/A
type: SIO_000616
description: 700

N/A
type: SIO_000616

N/A
type: SIO_000616
description: Familybased, 1000 independent cases

UDES
type: SIO_000616
description: Cohort of treated T2DM patients. Complete pharmacy, hospitalization,questionnaire, GP and laboratory data.

Cohort on Diabetes and Atherosclerosis
type: SIO_000616
description: 7 years follow-up data available for n=489

Severely Obese Individuals Maastricht
type: SIO_000616
description: Biopsies were taken during elective bariatric surgery.Blood was taken in fasted state on morning before surgery. Specimens for histological assessment are available. Other data available: BMI, age, waist-to-hip ratio, gender, blood measurements

N/A
type: SIO_000616
description: Extensive clinical data

N/A
type: SIO_000616
description: e.g. IBD, pancreatitis, hepatitis, PCLD

N/A
type: SIO_000616
description: Familybased, 600 independent cases

N/A
type: SIO_000616

N/A
type: SIO_000616
description: Familybased, 150 independent cases

IBD Zuid Limburg Biobank
type: SIO_000616
description: May 2011: 650 patients 50 controls (parents partners) collecting 50 patients each month. All currently available biobanks for inflammatory bowel disease are collected in referral centers and therefore severe disease and mostly Crohn's disease is over represented. In 1991 we started with a population based registration of all (+/- 3000) IBD patients in Zuid Limburg, The Netherlands. The registration contains 95% of the patients due to excellent collaboration of the 3 hospitals in the region. WE obtained METC approval to biobank this cohort + controls (partners and parents) in march 2011.

Amsterdam cohort study
type: SIO_000616
description: n=734 HIV+, incl. 335 with accurately imputed seroconversion date, AIDS event n= 180. Cells and plasma of all (>55.000 vaible frozen PBMC samples, longitudinally collected with 2-20 years of follow-up, 3-4 blood donations/yr. DNA ready from converters

Amsterdam cohort study2
type: SIO_000616
description: n=414 HIV+, incl. 120 seroconverters, AIDS n= 132. Cells and plasma of all, (>23.000 viable frozen PBMC samples, longitudinally collected with 2-20 years of follow-up, 2-3 blood donations/yr. DNA ready from converters

HIV Host genetics cohort
type: SIO_000616
description: n=600 HIV+ with known date of infection and clinical follow-up data. Stored plasma of all, DNA ready from 280

Amsterdam
type: SIO_000616

TB Indonesia
type: SIO_000616
description: Patient based

MeninGene
type: SIO_000616
description: Ongoing nationwide prospective cohort study in 90 hospitals since March 2006; coverage of 95% of all Dutch adults with community-acquired bacterial meningitis. Extensive clinical database, DNA, CSF, and causative bacteria; including controls matched for age, ethnicity, socio-economic status, and bacterial exposure.

AMC Renal Transplant Biobank
type: SIO_000616
description: Patient based, with a focus on CMV-immunity and allo-immunity

VUMC-BM cohort
type: SIO_000616

GIFT
type: SIO_000616
description: Affected sib-pairs

N/A
type: SIO_000616
description: Familybased, 700 independent cases

CuraSAB
type: SIO_000616

N/A
type: SIO_000616

EU-PACT
type: SIO_000616
description: Trial: genotyping before start coumarin therapy. To be included in 2010-2011: 1200 NL, total in Europe 3000

NUBIN AD
type: SIO_000616
description: very rich phenotyping available

Cluster
type: SIO_000616
description: Clinic based

Frontotemporal Dementia ErasmusMC
type: SIO_000616
description: Prospective cohort of FTD patients for genetic and biomarker research. Also information on MRI/CT scans, demographics, NPA, family history, genotypes, pathology available.

GEM
type: SIO_000616
description: Population based; MRI data on 450

Costa Rica
type: SIO_000616
description: Trio's

LUMINA
type: SIO_000616
description: Clinic based

NUBIN MS
type: SIO_000616

NBB
type: SIO_000616
description: autopsy cohort and 2250 registered brain donors

N/A
type: SIO_000616
description: Population based

GARP
type: SIO_000616
description: Affected sib-pairs

Early Arthritis Clinic Cohort (EAC), BEST
type: SIO_000616
description: Patient based

N/A
type: SIO_000616
description: 450 long follow-up. For part of the patients we have RNA and serum/plasma available.

UMCG
type: SIO_000616

N/A
type: SIO_000616
description: 500 families

N/A
type: SIO_000616
description: adult patients

N/A
type: SIO_000616
description: Familybased, 300 independent cases

N/A
type: SIO_000616
description: 150 families

NESDA
type: SIO_000616
description: 2981 respondents, mainly depression/anxiety cases but also >500 healthy controls. NB Also info on metabolic syndrome, migraine, and other phenotyes.

N/A
type: SIO_000616
description: 150 early dyslexia precursor research trios

N/A
type: SIO_000616
description: 120 sib pair families

N/A
type: SIO_000616
description: Familybased, 500 independent cases

N/A
type: SIO_000616
description: Familybased, 600 independent cases

NL Perinatal screening
type: SIO_000616
description: Anonymized, for SNP/risk factor allele frequency analysis

Netherlands Cohort Study on Diet and Cancer
type: SIO_000616
description: Prospective population-based cohort (n=120000), men and women, baseline in 1986; 20 years follow-up of cancer incidence and mortality.

OMEGA
type: SIO_000616
description: Prospective cohort focused on IVF-treatment Contact: Floor van Leeuwen

TEAM
type: SIO_000616
description: Nationally coordinated assessment of international randomized clinical trials

N/A
type: SIO_000616
description: Nationally coordinated assessment of international randomized clinical trials

N/A
type: SIO_000616
description: prospective cohort

N/A
type: SIO_000616
description: 50-100 vials per individual; well characterized individuals

SERIN
type: SIO_000616
description: independent isolates

N/A
type: SIO_000616
description: Patient based

Erasmus MC Tissue Bank
type: SIO_000616
description: 80,000 frozen tissue, 3,000,000 FFPE tissue blocks. Vele verschillende soorten studies worden op de weefsels gedaan door wetenschappers die de samples nodig hebben voor hun onderzoek. De samples worden benaderd met een grote verscheidenheid aan technieken. Veel kanker onderzoek naar Â biomarkers en targets, maar ook voor het testen, valideren en proberen van verschillende technieken

HEalthy LIfe in an Urban Setting
type: SIO_000616
description: Helius is started per december 2010 and will enroll 60.000 inhabitants of Amsterdam from six ethnic groups: hindu-Surinamese, Creole-Surinamese, Turkish, Moroccan, Ghanese and autochtonous Dutch. Parallel studies will be set up in countries of origin and the first is already started in Paramaribo. A small health investigation and an extensive questionnaire are focussed on cardiovascular and mental health and infectious diseases (www.heliusstudy.nl)

TRAILS2
type: SIO_000616
description: Clinical sample of children who were referred to child psychiatric services before age 11. Complementary to the TRAILS population cohort to oversample "vulnerableâ participants. See website www.trails.nl for more info and publications

Athero-Express Biobank Study
type: SIO_000616
description: Sample sizes of various biomaterial may vary due to unavailability (empty vials).

AAA-Express Biobank Study
type: SIO_000616
description: The majority of this biobank contains AAA-material, but also includes aneurysms from other vessels. Sample sizes of various biomaterial may vary due to unavailability (empty vials).

GARP + RAAK study
type: SIO_000616

PALGA
type: SIO_000616
description: The samples are stored in the 54 pathology laboratories in the Netherlands; PALGA plays an intermediate role between researches and pathology laboratories.

GEOLynch
type: SIO_000616
description: The GEOLynch cohort is an ongoing prospective cohort study designed to investigate the relationship between nutrition, lifestyle, genetic susceptibility and the occurrence of colorectal tumors among persons with an inherited mutation in a mismatch repair gene (Lynch Syndrome).

The Nightingale Study
type: SIO_000616
description: Occupational exposures and chronic diseases; focus on shift work and breast cancer. 62.000 participants with questionnaire data; 80% also donated toenails

New Hoorn Study
type: SIO_000616
description: Population based cohort study; all extensively phenotyped

Diabetes Care System West-Friesland
type: SIO_000616
description: Longitudinal cohort of diabetes patients with yearly follow-up data

De Maastricht Studie
type: SIO_000616
description: Population based cohort study. Final target n = 10,000 (2,000 per year): 5,000 type 2 diabetes and 5,000 general population. Extensively phenotyped in four different visits: anthropometrics, lung function, vascular function, exercise, MRI, CT. Start of study January 2011.

Dutch Hodgkin's Lymphoma Cohort
type: SIO_000616

BinnensteBuiten
type: SIO_000616
description: DSM diagnosis available + CBCL data + additional data on questionnaires

CORRBI
type: SIO_000616

MYST
type: SIO_000616
description: 600 myopia, 600 controls

AMC psychiatry
type: SIO_000616
description: Cortical tissue and cortical fluid will be collected in subset of patients during Deep Brain Stimulation surgery

dataILD
type: SIO_000616
description: Collection of clinical data and body specimen of patients with interstitial lung diseases, mainly sarcoidosis and lung fibrosis, but also ultra rare diseases like lymphangioleiomyomatosis and pulmonary alveolar proteinosis . Patients have signed informed consent.

ID1000
type: SIO_000616
description: population based cohorts, with multiple phenotypes, including MRI measures, cognition, and questionnaire data

Biobank UMCG
type: SIO_000616
description: All patient data in PALGA, no cohort studies.

Association study of coronary heart disease (CHD) Risk factors in the Genome using an Old-versus-young Setting
type: SIO_000616
description: ARGOS: The âAssociation study of coronary heart disease (CHD) Risk factors in the Genome using an Old-versus-young Settingâ (ARGOS-NL) population consisted of 500 patients, who were selected from 17000 FH patients with an identified causal mutation in the LDLR gene (segregating in the families and not present in controls) from the nationwide molecular screening program for FH. They were recruited from 38 lipid and cardiology clinics in the Netherlands in the nationwide molecular screening program of the âStichting Opsporing Erfelijke Familiare Hypercholesterolemie (StOEH)â.9 Phenotypic data (including CHD events) were acquired from general practitioners and by reviewing medical records at the lipid and cardiologic clinics. Hartstichting number NHS-2006B190

U-TWIN
type: SIO_000616
description: largely twin-pairs, including concordant and discordant for disease and healthy. MRI-scans performed

Hongerwinter Families (HoF) studie
type: SIO_000616
description: Prenatal nutrition long term effects, fetal origins In collaboration with Columbia University NY

NEO-Study
type: SIO_000616
description: Metabolomics, Fasting and posprandial (Total volume ~ 200ml) http://www.ncbi.nlm.nih.gov/pubmed/23576214

Netherlands Twin Register
type: SIO_000616
description: Includes MZ twins. Target= >10,000. Source for several studies (f.i. NETSAD, NETAMB, NETSMOK, Covamaer)

Parel Ischemische hartziekten
type: SIO_000616

Parel Oesofagus Maag tumoren
type: SIO_000616

Parel Nierfalen
type: SIO_000616
description: Objective is to better understand early forms of renal failure, affecting some 1650 patients each year, so as to improve prevention of its end stage and of the associated cardiovascular conditions.

Parel Multipele Endocriene Neoplasie
type: SIO_000616

Parel Cerebro vasculair accident
type: SIO_000616
description: Objective is to improve treatment possibilities and to prevent new infarctions and haemorrhages for 120,000 patients living with the consequences of a stroke.

Parel Leukemie, Myeloom, Lymfeklierkanker
type: SIO_000616
description: Objective is to facilitate the rapid introduction of new diagnostics, treatments and therapies tailored to the needs of the individual patient, according to the genetic characteristics of their particular tumour. In the Netherlands, about 1500 people a year are diagnosed with leukaemia and more than 1100 die of the condition.

Parel Inflammatoire darmziekten
type: SIO_000616
description: Objective is to better understand the causes of this group of conditions and the effectiveness of medicines and treatment for 60,000 patients with a chronic inflammation of the digestive tract.

Parel Reuma
type: SIO_000616
description: Objective is to prevent long-term invalidity for the 210,000 patients with rheumatoid arthritis and arthrosis.

Parel Parkinson
type: SIO_000616

Parel Diabetes
type: SIO_000616
description: Objective is to improve front-line care in anticipation of a sharp rise in the number of diabetes patients from the current figure of about 600,000.

Parel Neurodegeneratieve hersenziekten
type: SIO_000616
description: Klinische data, inclusief beelden

Parel Pancreas
type: SIO_000616
description: Het doel van de PancreasParel is het verzamelen van pancreasweefsel en bloed bij elke electieve pancreasoperatie (ongeacht de indicatie) ten behoeve van wetenschappelijk onderzoek naar pancreas- en peri-ampullaire tumoren en chronische pancreatitis.

Parel Erfelijke darmkanker
type: SIO_000616
description: To improve prevention, treatment and the quality of care for patients with some form of hereditary colorectal cancer, who currently number approximately 4000.

Parel CONCOR
type: SIO_000616
description: Objective is to better understand the long-term complications and genetic causes associated with congenital heart defects. An estimated 50,000 people in the Netherlands are living with such a condition, half of them aged over 18. doel: oorzaken en late uitkomsten van aangeboren hartafwijkingen. Van 15.000 patienten klinische gegevens en toestemming voor DNA bepaling.